C195

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C195

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(2S,3R,4S)-α-(Carboxycyclopropyl)glycine

solid

Synonym:(2S,3R,4S)-CCG, L-CCG-IV, (2S,1′R,2′S)-2-(2-Carboxycyclopropyl)glycine
CAS Number:117857-95-1
Linear Formula:C6H9NO4
Molecular Weight:159.14
MDL number:MFCD00210186

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Description

Biochem/physiol ActionsPotent NMDA receptor agonist.

Properties

formsolid
optical activity[α]/D +69.5°, c = 0.4 in H2O(lit.)
color off-white
solubilityH2O: soluble

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

References

referenceKawai, et al., 2-(Carboxycyclopropyl)glycines: Bindingneurotoxicity and induction of intracellular free calcium increase. Eur. J. Pharmacol. 211, 195, (1992)
 Yamashita, H., et al. Eur. J. Pharmacol. 289, 387, (1995)
 Kudo, et al., A significant increase in intracellular calcium concentration induced by (2S,3R,4S)-(carboxycyclopropyl)glycine, a new potent NMDA agonist, in cultured rat hippocampal neurons. Brain Res. 567, 342, (1991)
 Hayashi, et al., Agonist analysis of 2-(carboxy-cyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in chinese hamster ovary cells. Br. J. Pharmacol. 107, 539, (1992)